![]() ![]() Reverse causality may exist, and future prospective randomized clinical trials are warranted to determine the effect of PA on mortality in PD. Individuals who started PA after receiving the PD diagnosis had a lower mortality rate than those who remained physically inactive (HRs: vigorous, 0.82 moderate, 0.69 light, 0.86 ).Ĭonclusions and Relevance This analysis found a dose-response association between PA and all-cause mortality in PD. Individuals with PD who were physically active both before and after the PD diagnosis had the greatest reduction in mortality rate across all PA intensities (HRs: vigorous, 0.66 moderate, 0.49 light, 0.76 ). Moreover, maintenance of PA was associated with the mortality rate. There was a significant inverse dose-response association between the total amount of PA and mortality (HRs: vigorous, 0.80 moderate, 0.66 light, 0.81 P < .001). The mortality rate was lower among individuals who were physically active vs inactive at all PA intensities (vigorous: hazard ratio, 0.80 moderate: HR, 0.66 light: HR, 0.81 ). ![]() During the 8-year follow-up period, there were 1823 deaths (17%). A total of 10 699 individuals with PD were included 4925 (46%) were male and 5774 (54%) were female, and the mean (SD) age was 69.2 (8.8) years. Results A total of 45 923 individuals were identified 10 987 were enrolled, and 34 individuals younger than 40 years and 254 with missing data were excluded. Main Outcomes and Measures All-cause mortality. Those aged younger than 40 years or with missing data were excluded.Įxposures Physical activity levels were collected using self-reported questionnaires. Individuals who underwent health checkups within 2 years before and after the PD diagnosis were enrolled. Individuals who were newly diagnosed with PD were selected using the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision code G20 and registration code V124 in the program for rare intractable diseases in 2010 through 2013. Data were analyzed from September 2020 to March 2021. Participants were included from January 1, 2010, and December 31, 2013, and were followed up until December 31, 2017. Objective To evaluate the association between PA and mortality in individuals with PD and determine how the amount and maintenance of PA are associated with mortality.ĭesign, Setting, and Participants This nationwide population-based cohort study used Korean National Health Insurance System data. Importance The protective effects of physical activity (PA) against Parkinson disease (PD) development have been suggested however, the association of PA with mortality in PD has rarely been investigated.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |